High resolution 4-head pinhole SPECT system for small animal studies

We describe a newly developed ultra-high resolution SPECT
system using four pinhole collimators for small animal studies.
Methods:Thesystemutilizesa clinicalfour-headSPECTscan
ner with Specially designed pinhole collimators. Four types of
pinholes with different configurations were designed with differ
ant effective aperture sizes (1.0, 2.0 and 4.0 mm) and rotating
radii (40 mm and 50 mm). The distance from the axis of rotation
to the scintillatorwas fixed to 180 mm. A fltteredbackprojection
algorithm was used to reconstruct SPECT images after fan
beam-to-parallel-beam data conversion. Results The system
provided a reconstructed spatial resolution of 1.65 mm (FWHM)
and sensitivity of 4.3 kcps/@tCVmlwith the best type of pinholes,
respectively. The @rc-HMPAOSPECT image in rat studies
clearly visualized small brain structures, and the left ventricular
myocardium and cardiac cavity were clearly separated with
@Tc-MlBl. IYynamic SPECT imaging of rat brain with
r23oiom@enilwas also feasible.Conclusion:This uttra-high
resolution SPECT system can be used to measure the regional
distribution of radiolabeled tracers in small animals in vn,o and
may play a significantrole in the development of new radio
pharmaceuticals and in studies of various disease models using
living animals.

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Author or Creator: 
Ishizu K
Mukai T
Yonekura Y
Pagani M
Fujita T
Magata Y
Nishizawa S
Tamaki N
Shibasaki H
Konishi J
Society of Nuclear Medicine., [New York], Stati Uniti d'America
NM, Journal of nuclear medicine 36 (1995): 2282–2287.
info:cnr-pdr/source/autori:Ishizu K, Mukai T, Yonekura Y, Pagani M, Fujita T, Magata Y, Nishizawa S, Tamaki N, Shibasaki H and Konishi J/titolo:High resolution 4-head pinhole SPECT system for small animal studies/doi:/rivista:NM, Journal of nuclear medici
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