Functional Semi-Blind Source Separation Identifies Primary Motor Area Without Active Motor Execution

High time resolution techniques are crucial for investigating the brain in action. Here, we propose a method to identify a section of the upper-limb motor area representation (FS-M1) by means of electroencephalographic (EEG) signals recorded during a completely passive condition (FS-M1bySS). We delivered a galvanic stimulation to the median nerve and we applied to EEG the semi-Blind Source Separation (s-BSS) algorithm named Functional Source Separation (FSS). In order to prove that FS-M1bySS is part of FS-M1, we also collected EEG in a motor condition, i.e. during a voluntary movement task (isometric handgrip) and in a rest condition, i.e. at rest with eyes open and closed. In motor condition, we show that the cortico-muscular coherence (CMC) of FS-M1bySS does not differ from FS- M1 CMC (0.04 for both sources). Moreover, we show that the FS-M1bySS's ongoing whole band activity during Motor and both rest conditions displays high mutual information and time correlation with FS-M1 (above 0.900 and 0.800, respectively) whereas much smaller ones with the primary somatosensory cortex S1 (about 0.300 and 0.500, p < 0.001). FS-M1bySS as a marker of the upper-limb FS-M1 representation obtainable without the execution of an active motor task is a great achievement of the FSS algorithm, relevant in most experimental, neurological and psychiatric protocols.

Publication type: 
Author or Creator: 
Porcaro, Camillo
Cottone, Carlo
Cancelli, Andrea
Salustri, Carlo
Tecchio, Franca
World Scientific., Singapore, Singapore
International journal of neural systems 28 (2018). doi:10.1142/S0129065717500472
info:cnr-pdr/source/autori:Porcaro, Camillo; Cottone, Carlo; Cancelli, Andrea; Salustri, Carlo; Tecchio, Franca/titolo:Functional Semi-Blind Source Separation Identifies Primary Motor Area Without Active Motor Execution/doi:10.1142/S0129065717500472/rivis
Resource Identifier:
ISTC Author: 
Franca Tecchio's picture
Real name: 
Camillo Porcaro's picture
Real name: