Role of PET and SPECT in the study of amyotrophic lateral sclerosis.

Amyotrophic lateral sclerosis has been defined as a "heterogeneous group of neurodegenerative syndromes characterized by progressive muscle paralysis caused by the degeneration of motor neurons allocated in primary motor cortex, brainstem, and spinal cord." A comprehensive diagnostic workup for ALS usually includes several electrodiagnostic, clinical laboratory and genetic tests. Neuroimaging exams, such as computed tomography, magnetic resonance imaging and spinal cord myelogram, may also be required. Nuclear medicine, with PET and SPECT, may also play a role in the evaluation of patients with ALS, and provide additional information to the clinicians. This paper aims to offer to the reader a comprehensive review of the different radiotracers for the assessment of the metabolism of glucose (FDG), the measurement of cerebral blood flow (CBF), or the evaluation of neurotransmitters, astrocytes, and microglia by means of newer and not yet clinically diffuse radiopharmaceuticals.

Tipo Pubblicazione: 
Articolo
Author or Creator: 
Cistaro, Angelina
Cuccurullo, Vincenzo
Quartuccio, Natale
Pagani, Marco
Valentini, Maria Consuelo
Mansi, Luigi
Publisher: 
Hindawi Publishing Corporation, Cairo, Egitto
Source: 
BioMed Research International (Online) 2014 (2014). doi:10.1155/2014/237437
info:cnr-pdr/source/autori:Cistaro, Angelina; Cuccurullo, Vincenzo; Quartuccio, Natale; Pagani, Marco; Valentini, Maria Consuelo; Mansi, Luigi/titolo:Role of PET and SPECT in the study of amyotrophic lateral sclerosis./doi:10.1155/2014/237437/rivista:BioM
Date: 
2014
Resource Identifier: 
http://www.cnr.it/prodotto/i/324049
https://dx.doi.org/10.1155/2014/237437
info:doi:10.1155/2014/237437
Language: 
Eng
ISTC Author: 
Ritratto di Marco Pagani
Real name: