Extrastriatal binding of [123I]FP-CIT in the thalamus and pons: gender and age dependencies assessed in a European multicentre database of healthy controls

Purpose Apart from binding to the dopamine transporter
(DAT), [123I]FP-CITshows moderate affinity for the serotonin
transporter (SERT), allowing imaging of both monoamine
transporters in a single imaging session in different brain
areas. The aim of this study was to systematically evaluate
extrastriatal binding (predominantly due to SERT) and its age
and gender dependencies in a large cohort of healthy controls.
Methods SPECT data from 103 healthy controls with welldefined
criteria of normality acquired at 13 different imaging
centres were analysed for extrastriatal binding using volumes
of interest analysis for the thalamus and the pons. Data were
examined for gender and age effects as well as for potential
influence of striatal DAT radiotracer binding.
Results Thalamic binding was significantly higher than pons
binding. Partial correlations showed an influence of putaminal
DAT binding on measured binding in the thalamus but not on
the pons. Data showed high interindividual variation in
extrastriatal binding. Significant gender effects with 31 %
higher binding in women than in men were observed in the
thalamus, but not in the pons. An age dependency with a
decline per decade (±standard error) of 8.2±1.3 % for the
thalamus and 6.8±2.9 % for the pons was shown.
Conclusion The potential to evaluate extrastriatal predominant
SERT binding in addition to the striatal DAT in a single
imaging session was shown using a large database of [123I]FPCIT
scans in healthy controls. For both the thalamus and the
pons, an age-related decline in radiotracer binding was observed.
Gender effects were demonstrated for binding in the
thalamus only. As a potential clinical application, the data
could be used as a reference to estimate SERT occupancy in
addition to nigrostriatal integrity when using [123I]FP-CIT for
DAT imaging in patients treated with selective serotonin reuptake
inhibitors.

Tipo Pubblicazione: 
Articolo
Author or Creator: 
Koch, Walter H.
Unterrainer, Marcus
Xiong, Guoming
Bartenstein, Peter P.
Diemling, Markus
Varrone, Andrea
Dickson, John Caddell
Tossici-Bolt, Livia
Séra, Teréz
Asenbaum, Susanne
Booij, Jan
Kapucu, Özlem Lütfiye
Kluge, Andreas
Ziebell, Morten
Darcourt, Jacques
Nobili, Flavio Mariano
Pagani, Marco
Hesse, Swen
Vander Borght, Thierry M.
Van Laere, Koen Van R
Tatsch, Klaus
La Fougère, Christian
Publisher: 
Springer., Heidelberg;, Germania
Source: 
European journal of nuclear medicine and molecular imaging (Print) 41 (2014): 1938–1946. doi:10.1007/s00259-014-2785-8
info:cnr-pdr/source/autori:Koch, Walter H.; Unterrainer, Marcus; Xiong, Guoming; Bartenstein, Peter P.; Diemling, Markus; Varrone, Andrea; Dickson, John Caddell; Tossici-Bolt, Livia; Séra, Teréz; Asenbaum, Susanne; Booij, Jan; Kapucu, Özlem Lütfiye; Kluge
Date: 
2014
Resource Identifier: 
http://www.cnr.it/prodotto/i/323573
https://dx.doi.org/10.1007/s00259-014-2785-8
info:doi:10.1007/s00259-014-2785-8
http://www.scopus.com/record/display.url?eid=2-s2.0-84901552024&origin=inward
Language: 
Eng
ISTC Author: 
Ritratto di Marco Pagani
Real name: